Lesvos is the birthplace of several famous people.

In archaic times, Arion developed the type of poem called dithyramb, the progenitor of tragedy, Terpander invented the seven note musical scale for the lyre, followed by the lyric poet Alcaeus, and the most famous poetess Sappho. Phanias wrote history. The seminal artistic creativity of those times brings to mind the myth of Orpheus to whom Apollo gave a lyre and the Muses taught to play and sing. When Orpheus incurred the wrath of the god Dionysus he was dismembered by the Maenads and of his body parts his head and his lyre found their way to Lesbos where they have "remained" ever since. Pittacus was one of the Seven Sages of Greece.

In classical times Hellanicus advanced historiography, Theophrastus, the father of botany, succeeded Aristotle as the head of the Lyceum. Aristotle and Epicurus lived there for some time, and it is there that Aristotle began systematic zoological investigations. In later times lived Theophanes, the historian of Pompey's campaigns, Longus wrote the famous novel Daphnis and Chloe, and much later the historian Doukas wrote the history of the early Ottoman Turks.

In modern times the poet Odysseus Elytis, descendant of an old family of Lesvos received the Nobel Prize.